The purpose of this brief is to provide a summary of the evidence at a global level of ‘who is missing out’ on programming to achieve an AIDS-free generation, and ‘which evidence-based interventions may be implemented with partners to improve both HIV and equity outcomes’. However, this is a global snapshot, and no one specific context will match the situation presented in this brief. An equitable children and AIDS response must be based on local data and experience to determine the most appropriate interventions.